Construction and Characterization of a Mirror-Image l-DNA i-Motif

Yawei Sun; Bo Yang; Yi Hua; Yuanchen Dong; Jianhan Ye; Jiqian Wang; Lijin Xu; Dongsheng Liu

doi:10.1002/cbic.201900576

Construction and Characterization of a Mirror-Image l-DNA i-Motif

Chembiochem. 2020 Jan 15;21(1-2):94-97. doi: 10.1002/cbic.201900576. Epub 2020 Jan 3.

Authors

Yawei Sun¹, Bo Yang², Yi Hua², Yuanchen Dong³, Jianhan Ye³, Jiqian Wang¹, Lijin Xu⁴, Dongsheng Liu²

Affiliations

¹ State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum (Huadong), Qingdao, 266580, P. R. China.
² Key Lab of Organic Optoelectronics and, Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
³ CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Science, Beijing, 100084, P. R. China.
⁴ Department of Chemistry, Renmin University, Beijing, 100084, P. R. China.

PMID: 31659823
DOI: 10.1002/cbic.201900576

Abstract

The first thermally stable and pH-responsive quadruplex intercalated motif (i-motif) structure formed by l-DNA is presented. Although this l-type i-motif exhibits the same physiochemical properties as its d isomer, its inverted chirality and good enzymatic resistance potentially open the way to the development of new DNA materials of pharmaceutical and biological interest.

Keywords: DNA structures; chirality; i-motifs; l-DNA; self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Hydrogen-Ion Concentration
Nucleic Acid Conformation
Nucleotide Motifs
Thermodynamics

Substances

DNA