Disseminated Emergomyces pasteurianus Infection in India: A Case Report and a Review

Mycopathologia. 2020 Feb;185(1):193-200. doi: 10.1007/s11046-019-00387-y. Epub 2019 Oct 28.

Abstract

We report here a case of disseminated Emergomyces pasteurianus infection from India in a patient with AIDS. The patient presented with weight loss, dyspnoea and multiple non-tender skin lesions over face, neck and chest over 3 months. The case was diagnosed by microscopy, histopathology of sample and isolation of fungus from skin lesion, breast nodule, bone marrow and sputum. The identification of the isolates was confirmed by sequencing internal transcribed spacer region of rDNA, beta-tubulin, actin and intein PRP8. The patient responded well to intravenous amphotericin B deoxycholate followed by itraconazole therapy.

Keywords: Disseminated infection; Emergomyces; HIV.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / microbiology
  • Actins / genetics
  • Adult
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • DNA, Intergenic / genetics
  • DNA, Ribosomal / genetics
  • Deoxycholic Acid / therapeutic use
  • Drug Combinations
  • Female
  • Humans
  • India
  • Inteins / genetics
  • Itraconazole / therapeutic use
  • Mycoses / diagnosis
  • Mycoses / genetics
  • Mycoses / microbiology*
  • Onygenales*
  • Tubulin / genetics

Substances

  • Actins
  • Antifungal Agents
  • DNA, Intergenic
  • DNA, Ribosomal
  • Drug Combinations
  • Tubulin
  • Deoxycholic Acid
  • Itraconazole
  • Amphotericin B
  • amphotericin B, deoxycholate drug combination