Abstract
We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.
Keywords:
Candida auris; Enterobacteriaceae; NDM; Pseudomonas aeruginosa; carbapenemase; polymicrobial infection.
Copyright © 2020 American Society for Microbiology.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Proteins / genetics*
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Candida / genetics
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Candida / isolation & purification*
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Candidiasis / diagnosis*
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Candidiasis / microbiology
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Critical Illness
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics
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Enterobacteriaceae / isolation & purification*
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Enterobacteriaceae Infections / diagnosis*
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Enterobacteriaceae Infections / microbiology
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Escherichia coli Proteins / genetics
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Female
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Humans
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India
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification
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Middle Aged
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / isolation & purification*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Escherichia coli Proteins
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beta lactamase NDM-5, E coli
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beta-Lactamases
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beta-lactamase NDM-1
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beta-lactamase OXA-181, E coli
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carbapenemase