Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

Chem Commun (Camb). 2019 Nov 26;55(95):14255-14258. doi: 10.1039/c9cc06839b.

Abstract

In this study, we constructed bioconjugates of targeting immune checkpoint B7-H3 antibody and chlorin e6 to treat non-small cell lung cancer under the guidance of spectroscopic photoacoustic and fluorescence imaging. The B7-H3-Ce6 conjugates could display effective tumor diagnosis and therapy and provide a novel approach for immunotherapy.

MeSH terms

  • A549 Cells
  • Animals
  • Antibodies / chemistry
  • Antibodies / immunology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / immunology
  • Antineoplastic Agents / pharmacology*
  • Carcinoma, Non-Small-Cell Lung / immunology
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Cell Survival / drug effects
  • Chlorophyllides
  • Humans
  • Immunotherapy
  • Lung Neoplasms / immunology
  • Lung Neoplasms / therapy*
  • Mice
  • Mice, Nude
  • Microscopy, Confocal
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / therapy
  • Optical Imaging
  • Photoacoustic Techniques
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / immunology
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / chemistry
  • Porphyrins / immunology
  • Porphyrins / pharmacology*
  • Spectrophotometry, Ultraviolet

Substances

  • Antibodies
  • Antineoplastic Agents
  • Chlorophyllides
  • Photosensitizing Agents
  • Porphyrins
  • phytochlorin