Simple Aggregation-Induced Emission-Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro

Chem Asian J. 2019 Dec 2;14(23):4160-4163. doi: 10.1002/asia.201901315. Epub 2019 Nov 28.

Abstract

Multifunctional nanoparticles were simply synthesized by mixing a TICT+AIE featured molecule (TPAPP-CHO) with PBS solution. The fluorescent (FL) dots entered the cells via energy-related endocytosis and were located in lysosome emitting green FL. This indicated that the nanoparticles were dissociated in the lysosome. Moreover, the synthesized nanoparticles (NPs) demonstrate potent cytotoxicity against human U87 glioblastoma cells by inducing cell apoptosis via triggering intracellular ROS overproduction.

Keywords: Aggregation-induced emission; Cancer therapy; Cell localization; Imaging; Multifunctional nanoparticles.

MeSH terms

  • Aniline Compounds / chemistry
  • Aniline Compounds / therapeutic use
  • Aniline Compounds / toxicity*
  • Apoptosis / drug effects*
  • Benzaldehydes / chemistry
  • Benzaldehydes / therapeutic use
  • Benzaldehydes / toxicity*
  • Cell Line, Tumor
  • Fluorescent Dyes / chemistry*
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Quantum Dots / chemistry
  • Quantum Dots / therapeutic use
  • Quantum Dots / toxicity*
  • Reactive Oxygen Species / metabolism
  • Thiadiazoles / chemistry
  • Thiadiazoles / therapeutic use
  • Thiadiazoles / toxicity*

Substances

  • Aniline Compounds
  • Benzaldehydes
  • Fluorescent Dyes
  • Reactive Oxygen Species
  • Thiadiazoles