Investigations into the Influence of Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin, and Phenacetin

Lie-Ding Shiau

doi:10.1021/acsomega.9b02102

Investigations into the Influence of Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin, and Phenacetin

ACS Omega. 2019 Oct 10;4(17):17352-17358. doi: 10.1021/acsomega.9b02102. eCollection 2019 Oct 22.

Author

Lie-Ding Shiau^{1

2}

Affiliations

¹ Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33302, Taiwan.
² Department of Urology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.

Abstract

A new method of data interpretation based on classical nucleation theory is proposed in this work to elucidate the influence of solvents on the pre-exponential nucleation factor and interfacial energy using the induction time data for three crystallization systems, including isonicotinamide, lovastatin, and phenacetin. In this method, the pre-exponential nucleation factor is replaced by the intrinsic nucleation factor multiplied by temperature and divided by solution viscosity. The proposed method is applied to study the nucleation kinetics of isonicotinamide, lovastatin, and phenacetin among various solvents using the induction time data measured in this work. The results indicate that the intrinsic nucleation factor increases linearly with increasing square root of interfacial energy in various solvents for each system.