Association between adiposity levels and cognitive impairment in the Chilean older adult population

J Nutr Sci. 2019 Oct 9:8:e33. doi: 10.1017/jns.2019.24. eCollection 2019.

Abstract

Although both obesity and ageing are risk factors for cognitive impairment, there is no evidence in Chile on how obesity levels are associated with cognitive function. Therefore, the aim of the present study was to investigate the association between adiposity levels and cognitive impairment in older Chilean adults. This cross-sectional study includes 1384 participants, over 60 years of age, from the Chilean National Health Survey 2009-2010. Cognitive impairment was evaluated using the Mini-Mental State Examination. BMI and waist circumference (WC) were used as measures of adiposity. Compared with people with a normal BMI, the odds of cognitive impairment were higher in participants who were underweight (OR 4·44; 95 % CI 2·43, 6·45; P < 0·0001), overweight (OR 1·86; 95 % CI 1·06, 2·66; P = 0·031) and obese (OR 2·26; 95 % CI 1·31, 3·21; P = 0·003). The associations were robust after adjustment for confounding variables. Similar results were observed for WC. Low and high levels of adiposity are associated with an increased likelihood of cognitive impairment in older adults in Chile.

Keywords: Adiposity; Ageing; CNHS, Chilean National Health Survey; Cognitive impairment; Elderly; MMSE, Mini-Mental State Examination; Obesity; WC, waist circumference.

MeSH terms

  • Adiposity*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging*
  • Body Mass Index
  • Chile
  • Cognitive Dysfunction / complications
  • Cognitive Dysfunction / epidemiology*
  • Cross-Sectional Studies
  • Female
  • Health Surveys
  • Humans
  • Life Style
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Obesity / complications
  • Obesity / epidemiology*
  • Overweight / complications
  • Overweight / epidemiology*
  • Prevalence
  • Risk Factors
  • Socioeconomic Factors
  • Waist Circumference
  • Young Adult