Complex systems such as the human brain or the Earth's climate consist of many subsystems interacting in intricate, nonlinear ways. Moreover, variability of such systems extends over broad ranges of spatial and temporal scales and dynamical phenomena on different scales also influence each other. In order to explain how to detect cross-scale causal interactions, we review information-theoretic formulation of the Granger causality in combination with computational statistics (surrogate data method) and demonstrate how this method can be used to infer driver-response relations from amplitudes and phases of coupled nonlinear dynamical systems. Considering complex systems evolving on multiple time scales, the reviewed methodology starts with a wavelet decomposition of a multi-scale signal into quasi-oscillatory modes of a limited bandwidth, described using their instantaneous phases and amplitudes. Then statistical associations, in particular, causality relations between phases or between phases and amplitudes on different time scales are tested using the conditional mutual information. As an application, we present the analysis of cross-scale interactions and information transfer in the dynamics of the El Niño Southern Oscillation. This article is part of the theme issue 'Coupling functions: dynamical interaction mechanisms in the physical, biological and social sciences'.
Keywords: causality; coupling; information transfer; synchronization; time scales.