Abstract
Addition of certain inhibitors of RNA or protein synthesis to cells cultured in 20% serum, but not 5% serum, induces the differentiation of mouse erythroleukemia cells. Differentiation also was induced by culture at a low serum concentration (0.1%) to starve cells to quiescence, then inducing division by exposing cells to either of two high-pH regimes.
MeSH terms
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Alanine / analogs & derivatives
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Alanine / pharmacology
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Animals
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Cell Differentiation*
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Cell Division*
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Cell Line
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Cycloheximide / pharmacology
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Friend murine leukemia virus
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Hydrogen-Ion Concentration
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Leukemia, Erythroblastic, Acute / pathology*
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Mice
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Mycophenolic Acid / pharmacology
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Protein Biosynthesis
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RNA, Ribosomal / biosynthesis
Substances
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RNA, Ribosomal
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alanosine
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Cycloheximide
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Mycophenolic Acid
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Alanine