cGMP signalling in cardiomyocyte microdomains

Nadja I Bork; Cristina E Molina; Viacheslav O Nikolaev

doi:10.1042/BST20190225

cGMP signalling in cardiomyocyte microdomains

Biochem Soc Trans. 2019 Oct 31;47(5):1327-1339. doi: 10.1042/BST20190225.

Authors

Nadja I Bork^{1

2}, Cristina E Molina^{1

2}, Viacheslav O Nikolaev^{1

2}

Affiliations

¹ Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
² German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg 20246, Germany.

PMID: 31652306
DOI: 10.1042/BST20190225

Abstract

3',5'-Cyclic guanosine monophosphate (cGMP) is one of the major second messengers critically involved in the regulation of cardiac electrophysiology, hypertrophy, and contractility. Recent molecular and cellular studies have significantly advanced our understanding of the cGMP signalling cascade, its local microdomain-specific regulation and its role in protecting the heart from pathological stress. Here, we summarise recent findings on cardiac cGMP microdomain regulation and discuss their potential clinical significance.

Keywords: biosensor; cGMP; cardiac; fluorescence resonance energy transfer; microdomain.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cyclic GMP / metabolism*
Humans
Myocytes, Cardiac / metabolism*
Second Messenger Systems
Signal Transduction*

Substances

Cyclic GMP