Contribution of Real-Time Xpert MTB/RIF Testing to Establishing Early Diagnosis of Pediatric Extrapulmonary Tuberculosis in a Nonendemic Setting: A Case Series

Hana Mijović; Yossef Al-Nasser; Ghada N Al-Rawahi; Ashley D Roberts

doi:10.1097/INF.0000000000002488

Contribution of Real-Time Xpert MTB/RIF Testing to Establishing Early Diagnosis of Pediatric Extrapulmonary Tuberculosis in a Nonendemic Setting: A Case Series

Pediatr Infect Dis J. 2019 Dec;38(12):1249-1251. doi: 10.1097/INF.0000000000002488.

Authors

Hana Mijović¹, Yossef Al-Nasser², Ghada N Al-Rawahi^{1

3}, Ashley D Roberts¹

Affiliations

¹ From the Division of Infectious Diseases, Department of Pediatrics.
² Division of General Pediatrics, Department of Pediatrics.
³ Division of Medical Microbiology, Department of Pathology and Laboratory Medicine, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia, Canada.

PMID: 31651811
DOI: 10.1097/INF.0000000000002488

Abstract

Microbiologic confirmation of pediatric extrapulmonary tuberculosis remains challenging, leading to diagnostic delays. In our retrospective case series, real-time molecular testing (Xpert MTB/RIF) on respiratory and extrapulmonary specimens resulted in a more rapid diagnosis of extrapulmonary tuberculosis in a nonendemic, high resource setting.

MeSH terms

Adolescent
Antibiotics, Antitubercular / pharmacology
Bone Diseases / diagnosis
Bone Diseases / microbiology
British Columbia
Child
Child, Preschool
Computer Systems*
Drug Resistance, Bacterial
Early Diagnosis
Female
Humans
Infant
Male
Medical Records
Microbial Sensitivity Tests
Molecular Diagnostic Techniques / methods*
Molecular Diagnostic Techniques / statistics & numerical data
Mycobacterium tuberculosis
Retrospective Studies
Sensitivity and Specificity
Tuberculosis / cerebrospinal fluid
Tuberculosis / diagnosis*
Tuberculosis, Lymph Node / diagnosis
Tuberculosis, Meningeal / diagnosis

Substances

Antibiotics, Antitubercular