Cobalt-Catalyzed Oxidative Annulation of Benzothiophene-[ b]-1,1-dioxide through Diastereoselective Double C-H Activation

Subban Kathiravan; Ian A Nicholls

doi:10.1021/acs.orglett.9b03158

Cobalt-Catalyzed Oxidative Annulation of Benzothiophene-[ b]-1,1-dioxide through Diastereoselective Double C-H Activation

Org Lett. 2019 Dec 20;21(24):9806-9811. doi: 10.1021/acs.orglett.9b03158. Epub 2019 Oct 25.

Authors

Subban Kathiravan¹, Ian A Nicholls¹

Affiliation

¹ Bioorganic & Biophysical Chemistry Laboratory, Department of Chemistry & Biomedical Sciences and Linnaeus University Centre for Biomaterials Chemistry , Linnaeus University , SE-391 82 Kalmar , Sweden.

PMID: 31651175
DOI: 10.1021/acs.orglett.9b03158

Abstract

The use of inexpensive base metal catalysis to perform C-H activation is an active field of research in organic synthesis. Described herein is a sustainable cobalt-catalyzed diastereoselective oxidative annulation/double C-H activation of benzothiophene-[b]-1,1-dioxide with aminoquinolinamides under mild reaction conditions for the synthesis of annulated benzothiophenes.