Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) of N-Carboxyanhydrides

Chloé Grazon; Pedro Salas-Ambrosio; Emmanuel Ibarboure; Alix Buol; Elisabeth Garanger; Mark W Grinstaff; Sébastien Lecommandoux; Colin Bonduelle

doi:10.1002/anie.201912028

Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) of N-Carboxyanhydrides

Angew Chem Int Ed Engl. 2020 Jan 7;59(2):622-626. doi: 10.1002/anie.201912028. Epub 2019 Nov 22.

Authors

Chloé Grazon^{1

2}, Pedro Salas-Ambrosio¹, Emmanuel Ibarboure¹, Alix Buol¹, Elisabeth Garanger¹, Mark W Grinstaff², Sébastien Lecommandoux¹, Colin Bonduelle¹

Affiliations

¹ CNRS, Bordeaux INP, LCPO, UMR 5629, Univ. Bordeaux, 33600, Pessac, France.
² Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA, USA.

PMID: 31650664
DOI: 10.1002/anie.201912028

Abstract

Reported here is the first aqueous ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs) using α-amino-poly(ethylene oxide) as a macroinitiator to protect the NCA monomers from hydrolysis through spontaneous in situ self-assembly (ISA). This ROPISA process affords well-defined amphiphilic diblock copolymers that simultaneously form original needle-like nanoparticles.

Keywords: amphiphiles; polymerization; self-assembly; synthetic methods; water.

Publication types

Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding