Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer

Med Res Rev. 2020 May;40(3):909-930. doi: 10.1002/med.21642. Epub 2019 Oct 25.

Abstract

This review explores recent work directed toward the development of nanoparticles (NPs) for multimodality cancer imaging and targeted cancer therapy. In the growing era of precision medicine, theranostics, or the combined use of targeted molecular probes in diagnosing and treating diseases is playing a particularly powerful role. There is a growing interest, particularly over the past few decades, in the use of NPs as theranostic tools due to their excellent performance in receptor target specificity and reduction in off-target effects when used as therapeutic agents. This review discusses recent advances, as well as the advantages and challenges of the application of NPs in cancer imaging and therapy.

Keywords: cancer; molecular imaging; multimodality imaging; nanoparticles; targeted therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diagnostic Imaging / methods
  • Humans
  • Magnetic Resonance Imaging / methods
  • Metal Nanoparticles / chemistry
  • Mice
  • Molecular Imaging / methods
  • Multimodal Imaging / methods*
  • Nanoparticles / chemistry*
  • Neoplasm Transplantation
  • Neoplasms / diagnostic imaging*
  • Neoplasms / therapy*
  • Patient Safety
  • Phototherapy / methods
  • Positron-Emission Tomography / methods
  • Precision Medicine / methods
  • Radiotherapy / methods
  • Solubility
  • Theranostic Nanomedicine