Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient

Richard I Kaplan; Brian K Do; Ronald C Gentile; Sanjay R Kedhar

doi:10.1016/j.ajoc.2019.100552

Cytomegalovirus retinitis after treatment with topical difluprednate in an aphakic eye of an immunocompetent patient

Am J Ophthalmol Case Rep. 2019 Sep 10:16:100552. doi: 10.1016/j.ajoc.2019.100552. eCollection 2019 Dec.

Authors

Richard I Kaplan¹, Brian K Do^{1

2}, Ronald C Gentile^{1

3}, Sanjay R Kedhar^{1

4}

Affiliations

¹ Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY, USA.
² USC Roski Eye Institute, Keck School of Medicine at University of Southern California, Los Angeles, CA, USA.
³ Department of Ophthalmology, NYU Winthrop Hospital, Mineola, NY, USA.
⁴ Gavin Herbert Eye Institute, University of California Irvine Health, Irvine, CA, USA.

Abstract

Purpose: To report a case of an immunocompetent 64-year-old man who developed cytomegalovirus (CMV) retinitis after using topical difluprednate.

Observations: A 64-year-old man with type 2 diabetes developed hemorrhagic retinitis while using topical difluprednate after penetrating keratoplasty. Polymerase chain reaction of the vitreous was positive for CMV DNA. Complete blood count was within normal limits and 4th generation human immunodeficiency virus assay was negative. The retinitis resolved with oral valgancyclovir and intravitreal foscarnet injections.

Conclusion and importance: CMV retinitis may occur after topical difluprednate in an immunocompetent patient.

Keywords: Cytomegalovirus retinitis; Difluprednate; Topical steroid.

Publication types

Case Reports