Unfavorable Outcome of Neuroblastoma in Patients With 2p Gain

Katarzyna Szewczyk; Aleksandra Wieczorek; Wojciech Młynarski; Szymon Janczar; Mariola Woszczyk; Zuzanna Gamrot; Radosław Chaber; Mariusz Wysocki; Monika Pogorzała; Mirosław Bik-Multanowski; Walentyna Balwierz

doi:10.3389/fonc.2019.01018

Unfavorable Outcome of Neuroblastoma in Patients With 2p Gain

Front Oncol. 2019 Oct 9:9:1018. doi: 10.3389/fonc.2019.01018. eCollection 2019.

Authors

Affiliations

¹ Department of Medical Genetics, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
² Department of Pediatrics Oncology and Hematology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
³ Department of Pediatric Oncology and Hematology, University Children's Hospital of Krakow, Krakow, Poland.
⁴ Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Lodz, Poland.
⁵ Unit of Pediatric Oncology and Hematology, City Hospital, Chorzow, Poland.
⁶ Clinic of Pediatric Oncology and Hematology, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland.
⁷ Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Abstract

Background: Amplification of the MYCN oncogene is the most unfavorable genetic factor in neuroblastoma patients. However, knowledge about the clinical impact of low-level multiplication of MYCN is still insufficient. Therefore, we aimed to investigate the disease course in patients with different copy number status of MYCN. Materials and Methods: We examined 105 children diagnosed with neuroblastoma from 2010 to 2018 in five pediatric oncology centers in Poland. We determined the MYCN status at diagnosis by the interphase FISH examination and assessed the clinical outcome in patients. Results: A total of 35% of tumors presented with chromosome 2 numerical changes, 20% had MYCN amplification and 16% revealed 2p gain. Unexpectedly, we observed very low overall survival and event free survival (EFS) rates in neuroblastomas with 2p gain, which were comparable with patients with MYCN amplification. Conclusions: The 2p gain alteration should be reported as a strong unfavorable prognostic marker in neuroblastoma patients.

Keywords: 2p gain; MYCN amplification; MYCN gain; neuroblastoma; structural chromosomal aberrations.