Neutrophils in Psoriasis

Chih-Chao Chiang; Wei-Jen Cheng; Michal Korinek; Cheng-Yu Lin; Tsong-Long Hwang

doi:10.3389/fimmu.2019.02376

Neutrophils in Psoriasis

Front Immunol. 2019 Oct 9:10:2376. doi: 10.3389/fimmu.2019.02376. eCollection 2019.

Authors

Chih-Chao Chiang^{1

2

3}, Wei-Jen Cheng^{1

4

5}, Michal Korinek^{6

7

8}, Cheng-Yu Lin⁶, Tsong-Long Hwang^{4

6

7

9

10

11}

Affiliations

¹ Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
² Supervisor Board, Taoyuan Chinese Medicine Association, Taoyuan, Taiwan.
³ Puxin Fengze Chinese Medicine Clinic, Taoyuan, Taiwan.
⁴ School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
⁵ Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁶ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁷ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
⁸ Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁹ Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
¹⁰ Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
¹¹ Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.

Abstract

Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting ~2-3% of the world population. The abundant presence of neutrophils in the psoriatic skin lesions serves as a typical histopathologic hallmark of psoriasis. Recent reports indicated that oxidative stress, granular components, and neutrophil extracellular traps from psoriatic neutrophils are related to the initial and maintenance phases of psoriasis. This review provides an overview on the recent (up to 2019) advances in understanding the role of neutrophils in the pathophysiology of psoriasis, including the effects of respiratory burst, degranulation, and neutrophil extracellular trap formation on psoriatic immunity and the clinical relationships.

Keywords: degranulation; immunity; neutrophil extracellular traps; neutrophils; psoriasis; respiratory burst.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Extracellular Traps / immunology*
Humans
Immunity, Innate*
Neutrophils / immunology*
Neutrophils / pathology
Psoriasis / immunology*
Psoriasis / pathology
Respiratory Burst / immunology*