A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40

Cell Mol Immunol. 2020 Jun;17(6):659-661. doi: 10.1038/s41423-019-0309-y. Epub 2019 Oct 24.

Authors

Andreas Spyrantis^#¹, Jana Krieger^#¹, Katja Stifter¹, Bernhard Otto Boehm^{2

3}, Reinhold Schirmbeck⁴

Affiliations

¹ Department of Internal Medicine I, Ulm University Hospital; Albert Einstein Allee 23, 89081, Ulm, Germany.
² Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
³ Imperial College London, London, UK.
⁴ Department of Internal Medicine I, Ulm University Hospital; Albert Einstein Allee 23, 89081, Ulm, Germany. reinhold.schirmbeck@uni-ulm.de.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Autoantigens / metabolism
CD8-Positive T-Lymphocytes / immunology*
Fatty Acids / metabolism*
Insulin / metabolism*
Islets of Langerhans / immunology*
Lymphocyte Activation / immunology*
Mice, Inbred C57BL
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / metabolism*
T-Lymphocytes / immunology*

Substances

Autoantigens
Fatty Acids
Ffar1 protein, mouse
Insulin
Receptors, G-Protein-Coupled