Abstract
Three new labdane-type diterpenoids, 6α-O-isovalerylnidorellol (1), (12S)-blumdane (2), and (12R)-epiblumdane (3), and three new bisnorditerpenoids, 6α-O-(3-methyl-2-butenoyl)sterebin A (5), 6α-O-angeloylsterebin A (6), and 6α-O-isovalerylsterebin A (7), plus 17 known compounds were isolated from Blumea aromatica. Their structures of the new compounds were proposed by detailed spectroscopic analysis. The absolute configuration at C-12 of blumdane (2) was determined by the modified Mosher's method. The anti-inflammatory and anti-immunosuppressive effects of these isolated compounds were assessed. Compounds 9, 16, and 23 (at 40 μM) showed a slight suppression of TNF-α production, but no or little effect on the expression of PD-L1 in granulocytic myeloid-derived suppressor cells was observed for all test compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Asteraceae / chemistry*
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Cell Line, Tumor
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Diterpenes / chemistry*
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Diterpenes / pharmacology*
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Female
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Humans
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Mice, Inbred BALB C
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Plant Leaves / chemistry
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Programmed Cell Death 1 Receptor / antagonists & inhibitors
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RAW 264.7 Cells
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Immunosuppressive Agents
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Programmed Cell Death 1 Receptor
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Tumor Necrosis Factor-alpha
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labdane