Purpose: To retrospectively analyze the factors influencing response, local progression, local progression-free survival (LPFS), and overall survival (OS) in patients with primary non-small cell lung cancer (NSCLC) after computed tomography (CT)-guided radiofrequency ablation (RFA).
Methods: From August 2012 to October 2017, 108 lesions of 108 patients who had undergone CT-guided RFA were analyzed in this study. Patients were followed after RFA continuously. Meanwhile, technical success rate, incomplete ablation rate, local progression, LPFS and OS were assessed.
Results: In all patients, 100% technical success rate was achieved. Incomplete ablation rate was 9.26% (10 of 108). Maximum diameter of lesions was associated with incomplete ablation. Maximum diameter of lesions, clinical stage, solitary lesion in the lung and treatments after initial RFA were significantly related to LPFS. Maximum diameter of lesions clinical stage, solitary lesion in the lung, histologic types and treatments after initial RFA were significantly related to OS.
Conclusions: Maximum diameter of lesions ≤3cm, early clinical stage, solitary lesion in the lung and RFA combined with cisplatin and carboplatin chemotherapy and/or tyrosine kinase inhibitors (TKI) all were positive factors of local efficacy and survival after RFA of primary NSCLC.