Sarcomas arise from uncontrolled cell growth in tissues of mesodermal origins, such as connective tissue, bone, cartilage, fat or muscle. Surgical resection is still considered the cornerstone in the treatment of sarcomas. However, in many cases where tumor is adjacent to vital structures like major vessels, other treatment modalities may be implemented. Irreversible electroporation (IRE), a new form of ablative technique has been introduced lately in the treatment of several types of sarcomas. Irreversible electroporation has shown promising results and survival improvement in primarily inoperable solid tumors and locally advanced cancers, including prostate, kidney, liver, bone and pancreatic cancers in close proximity to important structures. The aim of this review was to sum up the current knowledge and the future perspectives of the usage of IRE in the management of sarcomas. Our study indicates that IRE could possibly represent a potential therapeutic option in patients with advanced or metastatic sarcoma, when surgery is not indicated.