Copper-Catalyzed Diphenylation of P(O)-OH Bonds with Cyclic Diaryliodonium Salts

Gang Wang; Biquan Xiong; Congshan Zhou; Yu Liu; Weifeng Xu; Chang-An Yang; Ke-Wen Tang; Wai-Yeung Wong

doi:10.1002/asia.201901284

Copper-Catalyzed Diphenylation of P(O)-OH Bonds with Cyclic Diaryliodonium Salts

Chem Asian J. 2019 Dec 2;14(23):4365-4374. doi: 10.1002/asia.201901284.

Authors

Gang Wang¹, Biquan Xiong^{1

2}, Congshan Zhou¹, Yu Liu¹, Weifeng Xu¹, Chang-An Yang¹, Ke-Wen Tang¹, Wai-Yeung Wong²

Affiliations

¹ Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, 414006, P. R. China.
² Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, P. R. China.

PMID: 31646736
DOI: 10.1002/asia.201901284

Abstract

A copper-catalyzed diphenylation of P(O)-OH bonds with cyclic diaryliodonium salts is described. Valuable 2'-iodo substituted biaryl phosphinic/phosphoric acid esters were obtained in good to excellent yields, which could be further transformed to diversified building blocks for the synthesis of bioactive compounds, pharmaceuticals and functional materials.

Keywords: P(O)−OH bonds; copper catalysis; cyclic diaryliodonium salts; diphenylation.

Abstract

Grants and funding