Nanonetwork of Coordination Polymer AHMT-Ag for the Effective and Broad Spectrum Detection of 6-Mercaptopurine in Urine and Blood Serum

Vinita; Madhu Tiwari; Neha Agnihotri; Monika Singh; Akhilesh Kumar Singh; Rajiv Prakash

doi:10.1021/acsomega.9b01122

Nanonetwork of Coordination Polymer AHMT-Ag for the Effective and Broad Spectrum Detection of 6-Mercaptopurine in Urine and Blood Serum

ACS Omega. 2019 Oct 4;4(16):16733-16742. doi: 10.1021/acsomega.9b01122. eCollection 2019 Oct 15.

Authors

Vinita^{1

2}, Madhu Tiwari³, Neha Agnihotri⁴, Monika Singh¹, Akhilesh Kumar Singh¹, Rajiv Prakash¹

Affiliations

¹ School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.
² Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273009, India.
³ Department of Chemistry, K. N. Govt. P. G. College Gyanpur, Bhadohi 221304, India.
⁴ Department of Physics, National Institute of Technology, Jamshedpur 832109, India.

Abstract

Nanocrystalline coordination polymers (NCCPs) have been considered as an incredible electrochemical sensor for the effective detection of biologically dynamic drug 6-mercaptopurine (6-MP). In the present report, a significantly stable infinite arrayed coordination polymeric network was self-assembled via metal with efficient organic tecton 4-amino-3-hydrazino-5-mercapto-1,2,4,-triazole (AHMT) in which silver(I) ions are coordinated by AHMT via hydrazino and exocyclic thiol linkage to form AHMT-Ag NCCP. An efficient and highly sensitive detection of 6-MP is attained owing to eminent electron channeling via polymeric nanocrystallite pores. An effective charge transfer leads to an interface of the AHMT-Ag nano-pores and electrolyte anchored electrode via π-π electron coupling and hydrophobic interaction. The voltammogram exposes acute redox behavior of 6-MP and discloses an impeccable illustration for the AHMT-Ag facilitated oxidation of 6-MP. This unique signature was applied in voltammetric detection of 6-MP in blood serum, human urine, and pharmaceutical formulation (tablet) by a considerable high sensitivity of 0.074, 0.058, and 0.036 μA/μM and a detection limit of 87, 97, and 37 nM, respectively. Thus, the prepared AHMT-Ag NCCP can provide a valuable platform for fabrication of highly sensitive electrochemical devices to assay biologically essential drug molecules.