Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside

Jielai Yang; Fei Wang; Yong Lu; Jin Qi; Lianfu Deng; Flávia Sousa; Bruno Sarmento; Xiangyang Xu; Wenguo Cui

doi:10.1016/j.jconrel.2019.10.032

Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside

J Control Release. 2019 Nov 28:314:81-91. doi: 10.1016/j.jconrel.2019.10.032. Epub 2019 Oct 20.

Authors

Jielai Yang¹, Fei Wang², Yong Lu², Jin Qi², Lianfu Deng², Flávia Sousa³, Bruno Sarmento⁴, Xiangyang Xu⁵, Wenguo Cui⁶

Affiliations

¹ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China; Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China.
² Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China.
³ INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal.
⁴ INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal. Electronic address: bruno.sarmento@ineb.up.pt.
⁵ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China; Department of orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China. Electronic address: xu664531@163.com.
⁶ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China. Electronic address: wgcui80@hotmail.com.

PMID: 31644936
DOI: 10.1016/j.jconrel.2019.10.032

Abstract

Erythrocyte-mimicking nanovehicles (EM-NVs) are developed by fusing nanoparticle cores with naturally derived erythrocyte membranes. Compared with conventional nanosystems, EM-NVs hold preferable characteristics of prolonged blood circulation time and immune evasion. Due to the cell surface mimetic properties, along with tailored core material, EM-NVs have huge application potential in a large variety of biomedical fields, which are anticipated to revolutionize the present theranostic modalities of diseases in clinic. This review focuses on (I) drug carriers, (II) photosensitizers, (III) antidotes, (IV) vaccines and (V) probes, aiming to present an overall summary of the latest advancement in the application of EM-NVs, and highlight the major challenges and opportunities in this field.

Keywords: Biomedical application; Biomimetic; Erythrocyte; Nanovehicles.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biomimetic Materials / chemistry*
Drug Carriers / chemistry
Erythrocyte Membrane / chemistry
Erythrocytes / chemistry*
Humans
Nanoparticles*
Surface Properties
Theranostic Nanomedicine / methods

Substances

Drug Carriers