Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report

Harutake Sawazaki; Yujiro Tsujita; Yuji Ito

doi:10.1016/j.eucr.2019.101004

Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report

Urol Case Rep. 2019 Sep 5:27:101004. doi: 10.1016/j.eucr.2019.101004. eCollection 2019 Nov.

Authors

Harutake Sawazaki¹, Yujiro Tsujita², Yuji Ito³

Affiliations

¹ Department of Urology, Tama-hokubu Medical Center, 1-7-1 Aobacho, Higashimurayama, Tokyo, 189-8511, Japan.
² Department of Urology, Self-Defense Forces Central Hospital, 1 Chome-2-2-4 Ikejiri, Setagaya, Tokyo, Japan.
³ Department of Pathology, Tama-Hokubu Medical Center, 1-7-1 Aobacho, Higashimurayama, Tokyo, 189-8511, Japan.

Abstract

Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephrectomy was performed. Pathological diagnosis was MFH arising from the renal capsule. We used Ion AmpliSeq Cancer Hotspot Panel version 2 primers to perform gene mutation screening. We detected 13 mutations in 11 hotspot oncogenes (CSF1R, FGFR3, KDR, APC, PDGFRA, TP53, FLT3, ERBB4, KIT, STK11, RET), but these were not matched to driver mutations.

Keywords: Gene mutation screening; Malignant fibrous histiocytoma; Renal capsule.

Publication types

Case Reports