1 School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.
2 Laboratory of Therapeutic Innovation (UMR 7200), CNRS, University of Strasbourg, 67401, Illkirch, France.
3 School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK. alan.j.whitmarsh@manchester.ac.uk.