Objective: To investigate the relationship between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease (NAFLD).
Methods: A total of 120 patients with NAFLD admitted in our hospital between June and August, 2017 were enrolled and divided into 4 groups with different serum 25 (OH) vitamin D levels: >75 nmol/L (group A, n=25), 50-75 nmol/L (group B, n=35), 25-50 nmol/L (group C, n=32), and < 25 nmol/L (group D, n=28). For all the patients, serum 25 (OH) vitamin D level was measured by ELISA, and liver fat content was determined using in-phase opposed-phase T1WI sequences. The measurement data were compared among the 4 groups to assess the association between serum 25(OH) vitamin D level and liver fat content.
Results: The liver fat content appeared to be higher in group B (28.66±6.45%) and group C (38.74±11.47%) than in group A (22.79 ± 6.10%), but the difference was not statistically significant (P>0.05); the liver fat content in group D (54.79 ± 5.28%) was significantly higher than that in the other 3 groups (P>0.05). Liver fat content increased significantly as serum 25(OH) vitamin D level decreased, showing an inverse correlation between them in these patients (P < 0.05, r=-0.125).
Conclusions: In patients with NAFLD, a decreased serum 25(OH) vitamin D level is associated with an increased liver fat content, suggesting the value of serum 25(OH) vitamin D as a predictor of NAFLD.
目的: 探讨血清25(OH)维生素D与非酒精性脂肪肝(NAFLD)肝内脂肪含量的关系。
方法: 选取2017年6~8月我院健康体检及住院的NAFLD者120例，将患者分为血清25(OH)维生素D>75 nmol/L(n=25，A组)，50~75 nmol/L(n=35，B组)，25~ 50 nmol/L(n=32，C组)，< 25 nmol/L(n=28，D组)。采用ELISA法检测血清25(OH)维生素D浓度，应用T1WI同/反相位测定肝内脂肪含量。全部计量资料用均数±标准差表示，多组间比较采用方差分析及Spearman相关分析，两两比较采用LSD-t检验。P < 0.05表示差异有统计学意义。
结果: B组(28.66±6.45)%及C组(38.74±11.47)%肝脏脂肪含量高于A组(22.79±6.10)%，但差异无统计学意义(P>0.05)。D组(54.79±5.28)%肝脏脂肪含量高于A、B、C三组，差异有统计学意义(P>0.05)。随着血清25(OH)维生素D含量减低，肝脏脂肪含量升高，呈负相关关系(P < 0.05，r=-0.125)。
结论: 血清25(OH)维生素D越低，肝脏脂肪含量越高，血清25(OH)维生素D有望成为NAFLD的预测指标。
Keywords: liver fat content; nonalcoholic fatty liver disease; serum 25 (OH) vitamin D.