Application of natural products derivatization method in the design of targeted anticancer agents from 2000 to 2018

Weijie Liu; Qingshan Li; Junhua Hu; Hongxue Wang; Fengbo Xu; Qiang Bian

doi:10.1016/j.bmc.2019.115150

Application of natural products derivatization method in the design of targeted anticancer agents from 2000 to 2018

Bioorg Med Chem. 2019 Dec 1;27(23):115150. doi: 10.1016/j.bmc.2019.115150. Epub 2019 Oct 15.

Authors

Weijie Liu¹, Qingshan Li², Junhua Hu³, Hongxue Wang⁴, Fengbo Xu⁵, Qiang Bian⁶

Affiliations

¹ State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, NanKai University, TianJin 30007, China. Electronic address: weijieliu@mail.nankai.edu.cn.
² State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, NanKai University, TianJin 30007, China. Electronic address: qli@nankai.edu.cn.
³ Citus Research Institute, Southwest University, Chongqing 400716, China. Electronic address: hujunhua@cric.cn.
⁴ State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, NanKai University, TianJin 30007, China; National Pesticide Engineering Research Center, College of Chemistry, NanKai University, TianJin 300071, China. Electronic address: whongxue@nankai.edu.cn.
⁵ State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, NanKai University, TianJin 30007, China; National Pesticide Engineering Research Center, College of Chemistry, NanKai University, TianJin 300071, China. Electronic address: xufb@nankai.edu.cn.
⁶ National Pesticide Engineering Research Center, College of Chemistry, NanKai University, TianJin 300071, China. Electronic address: bianqiang@nankai.edu.cn.

PMID: 31635893
DOI: 10.1016/j.bmc.2019.115150

Abstract

A concept, natural products derivatization method (NPDM), was introduced to assess the influence of natural products on the discovery of targeted anticancer agents. Subsequently, 106 new molecular entities (NMEs) for targeted anticancer agents from 2000 to 2018 were categorized and sorted into four types: ND (Natural Product Derivative), SND (Synthetic Natural Derived), B (Biological Macromolecule), S (Totally synthetic in origin). Furthermore, by setting molecular targeted agents (MTA), cellular targeted agents (CTA), vascular targeted agents (VTA) and immuno targeted agents (ITA) as study subject, ND category and SND category were reviewed from aspects including natural products source, action mechanism and their share in all NMEs in order to comprehensively evaluate the significance of NPDM in the design and development of targeted anticancer agents, and the prospects of this method was also put forward.

Keywords: Natural products derivatization method; New molecular entities; Targeted anticancer agents.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use
Biological Products / chemistry*
Biological Products / pharmacology*
Biological Products / therapeutic use
Drug Design*
Drug Discovery / methods
Humans
Molecular Targeted Therapy / methods
Neoplasms / drug therapy*
Neoplasms / metabolism

Substances

Antineoplastic Agents
Biological Products