Development of bacterial cellulose/chitin multi-nanoﬁbers based smart films containing natural active microspheres and nanoparticles formed in situ

Yu-Ning Yang; Kun-Ying Lu; Pan Wang; Yi-Cheng Ho; Min-Lang Tsai; Fwu-Long Mi

doi:10.1016/j.carbpol.2019.115370

Development of bacterial cellulose/chitin multi-nanoﬁbers based smart films containing natural active microspheres and nanoparticles formed in situ

Carbohydr Polym. 2020 Jan 15:228:115370. doi: 10.1016/j.carbpol.2019.115370. Epub 2019 Sep 27.

Authors

Yu-Ning Yang¹, Kun-Ying Lu², Pan Wang³, Yi-Cheng Ho⁴, Min-Lang Tsai⁵, Fwu-Long Mi⁶

Affiliations

¹ Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan, ROC.
² Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei City 11031, Taiwan, ROC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan, ROC.
³ School of Public Health, College of Public Health, Taipei Medical University, Taipei City 11031, Taiwan, ROC.
⁴ Department of Bioagricultural Science, National Chiayi University, Chiayi 60004, Taiwan, ROC.
⁵ Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan, ROC. Electronic address: tsai5122@gmail.com.
⁶ Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan, ROC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan, ROC; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei City 11031, Taiwan, ROC. Electronic address: flmi530326@tmu.edu.tw.

PMID: 31635728
DOI: 10.1016/j.carbpol.2019.115370

Abstract

Nanofiber-based materials have recently gained increasing attention in food packaging, drug delivery, and biomedical applications. In this study, a multi-nanoﬁbers composite film was developed based on bacterial cellulose nanofiber (BCNF)/chitin nanofiber (CNF) hybridization. The nanofibers were responsible for the formation of well-dispersed curcumin (Cur) micro/nanoparticles in the nanocomposite films. The release of Cur from the films were affected by CNF and the sizes of Cur particles formed in situ. The Cur particles reduced tensile strength and increased water vapor permeability of BCNF film. However, CNF improved the mechanical strength and barrier property of the Cur/BCNF/CNF composite film. Moreover, the multi-nanoﬁbers composite film showed excellent dynamic antioxidant capacity and antibacterial activity, as well as was capable to monitor pH change and trace amount of boric acid. Results of this study suggested that the Cur/BCNF/CNF composite film can be used as a smart and active food packaging material.

Keywords: Active film; Antibacterial; Antioxidat; Bacterial cellulose nanofiber; Chitin nanofiber; Drug release.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Antioxidants / pharmacology
Cellulose / chemistry*
Chitin / chemistry*
Curcumin / pharmacology
Decapodiformes / metabolism
Drug Carriers
Drug Liberation
Escherichia coli / drug effects
Food Packaging
Microspheres
Nanocomposites / chemistry
Nanofibers / chemistry*
Nanoparticles / chemistry
Staphylococcus aureus / drug effects
Tensile Strength

Substances

Anti-Bacterial Agents
Antioxidants
Drug Carriers
Chitin
Cellulose
Curcumin