In the present study, a novel AgOx/BiPO₄ sensor was successfully prepared and used for detecting trans-resveratrol. Prepared samples were characterized using methods including X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy. The results demonstrate that the AgOx/BiPO₄ is composed of AgO, Ag₂O, and BiPO4. In addition, a cyclic voltammetry method was used to measure resveratrol concentration using the electrochemical sensor based on AgOx/BiPO₄. AgOx/BiPO₄ presents a well-defined voltammetric peak at approximately +460 mV versus Ag/AgCl in phosphate-buffered saline solution. In addition, the sensor exhibits a detection limit of 1.0×10-7 M, and the wide dynamic concentration ranges from 2.0×10-7 to 12.5×10-6 M. Stability and interference tests were performed for 20 days. A possible mechanism for AgOx/BiPO₄ detection of trans-resveratrol detection is proposed.