Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits

Ann Louise Hunter; David W Ray

doi:10.3390/biology8040079

Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits

Biology (Basel). 2019 Oct 19;8(4):79. doi: 10.3390/biology8040079.

Authors

Ann Louise Hunter¹, David W Ray²

Affiliations

¹ Centre for Biological Timing, Department of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK. louise.hunter@manchester.ac.uk.
² NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK and Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 9DU, UK. David.Ray@ocdem.ox.ac.uk.

Abstract

The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression.

Keywords: REV-ERBα; biological rhythms; circadian clock; cryptochrome; energy metabolism; liver.

Publication types

Review

Abstract

Publication types

Grants and funding