Pathology of Rotavirus-driven Multiple Organ Failure in a 16-month-old Boy

Pediatr Infect Dis J. 2019 Dec;38(12):e326-e328. doi: 10.1097/INF.0000000000002472.

Abstract

Autopsy investigation of a fatal case of rotavirus severe acute gastroenteritis and multiple organ failure in a 16-month boy with previous intrauterine growth retardation showed colocalization of nonstructural and structural rotavirus proteins within viroplasms in nephrons. This case brings new insights into extraintestinal rotavirus infection and new clues to its abilities to bind to human histo-blood group antigens.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / virology
  • Autopsy
  • Fatal Outcome
  • Fetal Growth Retardation
  • Gastroenteritis / complications*
  • Gastroenteritis / pathology
  • Gastroenteritis / virology*
  • Humans
  • Infant
  • Male
  • Multiple Organ Failure / virology*
  • Nephrons / virology
  • Rotavirus
  • Rotavirus Infections / complications*
  • Rotavirus Infections / diagnosis
  • Rotavirus Infections / pathology*
  • Shock, Septic / virology