The Hippo Signaling Pathway in Cardiac Development and Diseases

Masum M Mia; Manvendra K Singh

doi:10.3389/fcell.2019.00211

The Hippo Signaling Pathway in Cardiac Development and Diseases

Front Cell Dev Biol. 2019 Oct 1:7:211. doi: 10.3389/fcell.2019.00211. eCollection 2019.

Authors

Masum M Mia¹, Manvendra K Singh^{1

2}

Affiliations

¹ Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.
² National Heart Research Institute Singapore, National Heart Center, Singapore, Singapore.

Abstract

Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, loss of cardiomyocytes from injury or diseases in adults could lead to heart failure. The Hippo signaling pathway is a newly identified signaling cascade that modulates regenerative response by regulating cardiomyocyte proliferation in the embryonic heart, as well as in postnatal hearts after injury. In this review, we summarize recent findings highlighting the function and regulation of the Hippo signaling pathway in cardiac development and diseases.

Keywords: cardiac development; cardiomyoapthies; hippo signaling; hypertrophy; ischemia – reperfusion.

Publication types

Review