Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study

Yan Zheng; Yin Li; Wenqun Xing; Jianjun Qin; Xianben Liu; Ruixiang Zhang; Haibo Sun; Xiankai Chen

doi:10.2147/CMAR.S212192

Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study

Cancer Manag Res. 2019 Oct 11:11:8877-8883. doi: 10.2147/CMAR.S212192. eCollection 2019.

Authors

Yan Zheng^#¹, Yin Li^#^{1

2}, Wenqun Xing^#¹, Jianjun Qin^{1

2}, Xianben Liu¹, Ruixiang Zhang¹, Haibo Sun¹, Xiankai Chen^{1

2}

Affiliations

¹ Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People's Republic of China.
² Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma.

Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested.

Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043-2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p<0.001) or alcohol consumption (p<0.001), pathological N0 stage (P=0.002), and early pathological TNM stage (I-II) (P=0.004).

Conclusion: This research showed that preoperative serum fibrinogen is an independent prognostic factor for survival in ESCC, especially for the early pathological TNM stage (I-II) and N0 patients.

Keywords: esophageal cancer; prognostic factor; real world study; retrospective study; serum fibrinogen.