Target-triggered, self-powered DNAzyme-MnO2 nanosystem: towards imaging microRNAs in living cells

Mei-Rong Cui; Xiang-Ling Li; Jing-Juan Xu; Hong-Yuan Chen

doi:10.1039/c9cc06623c

Target-triggered, self-powered DNAzyme-MnO₂ nanosystem: towards imaging microRNAs in living cells

Chem Commun (Camb). 2019 Nov 5;55(89):13366-13369. doi: 10.1039/c9cc06623c.

Authors

Mei-Rong Cui¹, Xiang-Ling Li¹, Jing-Juan Xu¹, Hong-Yuan Chen¹

Affiliation

¹ State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. xlli@nju.edu.cn xujj@nju.edu.cn.

PMID: 31631205
DOI: 10.1039/c9cc06623c

Abstract

A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme-MnO2 nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.

MeSH terms

Cell Line, Tumor
Cell Survival*
DNA, Catalytic / chemistry*
DNA, Catalytic / metabolism
HeLa Cells
Humans
MCF-7 Cells
Manganese Compounds / chemistry*
Manganese Compounds / metabolism
MicroRNAs / analysis*
Nanoparticles / chemistry*
Nanoparticles / metabolism
Optical Imaging*
Oxides / chemistry*
Oxides / metabolism

Substances

DNA, Catalytic
Manganese Compounds
MicroRNAs
Oxides
manganese dioxide