Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Clin Infect Dis. 2020 Jun 24;71(1):201-204. doi: 10.1093/cid/ciz1000.

Abstract

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.

Keywords: antimicrobial resistance; group A Streptococcus; β-lactam resistance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Penicillin-Binding Proteins / genetics
  • Streptococcus pyogenes* / genetics
  • beta-Lactam Resistance* / genetics

Substances

  • Anti-Bacterial Agents
  • Penicillin-Binding Proteins