Associations of urinary phthalate metabolites with risk of papillary thyroid cancer

Hongjian Miao; Xin Liu; Jingguang Li; Lei Zhang; Yunfeng Zhao; Shaoyan Liu; Song Ni; Yongning Wu

doi:10.1016/j.chemosphere.2019.125093

Associations of urinary phthalate metabolites with risk of papillary thyroid cancer

Chemosphere. 2020 Feb:241:125093. doi: 10.1016/j.chemosphere.2019.125093. Epub 2019 Oct 11.

Authors

Hongjian Miao¹, Xin Liu², Jingguang Li¹, Lei Zhang³, Yunfeng Zhao¹, Shaoyan Liu⁴, Song Ni⁵, Yongning Wu¹

Affiliations

¹ NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, 100021, China.
² NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, 100021, China; Institute of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, Hubei, China.
³ NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, 100021, China. Electronic address: Zhanglei1@cfsa.net.cn.
⁴ Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China.
⁵ Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China. Electronic address: nisong@cicams.ac.cn.

PMID: 31629241
DOI: 10.1016/j.chemosphere.2019.125093

Abstract

Some studies have revealed thyrotoxicity of phthalates; however, associations of phthalate exposure with papillary thyroid cancer (PTC) remain unclear. We conducted a pair-matching case-control study of 111 PTC cases and 111 age- and sex-matched non-PTC controls to examine associations between urinary concentrations of phthalate metabolites and PTC. Phthalate metabolites were determined in fasting urine specimens by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS). After adjusting for potential confounders and other phthalate metabolites, the concentrations of the sum of di (2-ethylhexly) phthalate (DEHP) metabolites in urine were positively associated with PTC [odds ratio (OR) = 5.35; 95% confidence interval (CI): 1.61-17.83], suggesting the effect of phthalates exposure on PTC development. The findings require confirmation.

Keywords: Case-control study; Phthalate; Thyroid cancer; Urinary metabolites.

MeSH terms

Adult
Case-Control Studies
Chromatography, Liquid
Diethylhexyl Phthalate / urine
Environmental Exposure / adverse effects
Environmental Exposure / analysis
Female
Humans
Male
Middle Aged
Odds Ratio
Phthalic Acids / urine*
Tandem Mass Spectrometry
Thyroid Cancer, Papillary / chemically induced*
Thyroid Cancer, Papillary / urine
Thyroid Neoplasms / chemically induced*
Thyroid Neoplasms / urine

Substances

Phthalic Acids
phthalic acid
Diethylhexyl Phthalate