HLA-matched and HLA-haploidentical allogeneic CD19-directed chimeric antigen receptor T-cell infusions are feasible in relapsed or refractory B-cell acute lymphoblastic leukemia before hematopoietic stem cell transplantation

Leukemia. 2020 Mar;34(3):909-913. doi: 10.1038/s41375-019-0610-x. Epub 2019 Oct 18.

Authors

Xin Jin^#¹, Yaqing Cao^#², Luqiao Wang^#², Rui Sun², Lin Cheng², Xiaoyuan He¹, Xia Xiao³, Yili Jiang³, Qing Li³, Huan Zhang³, Wenyi Lu³, Cuicui Lyu³, Yanyu Jiang³, Juanxia Meng³, Mingfeng Zhao^{4

5}

Affiliations

¹ School of Medicine, Nankai University, Tianjin, 300071, China.
² The First Central Clinical College, Tianjin Medical University, Tianjin, 300070, China.
³ Department of Hematology, Tianjin First Central Hospital, Tianjin, 300192, China.
⁴ School of Medicine, Nankai University, Tianjin, 300071, China. mingfengzhao@sina.com.
⁵ Department of Hematology, Tianjin First Central Hospital, Tianjin, 300192, China. mingfengzhao@sina.com.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antigens, CD19 / immunology*
B-Lymphocytes / immunology
Female
HLA Antigens / immunology*
Hematopoietic Stem Cell Transplantation*
Humans
Immunotherapy, Adoptive*
Leukemia, B-Cell / immunology
Leukemia, B-Cell / therapy*
Male
Middle Aged
Neoplasm Recurrence, Local
Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Receptors, Chimeric Antigen / immunology
T-Lymphocytes / cytology
Treatment Outcome
Young Adult

Substances

Antigens, CD19
CD19 molecule, human
HLA Antigens
Receptors, Chimeric Antigen