Bioactive polyketides from the mangrove endophytic fungi Phoma sp. SYSU-SK-7

Yan Chen; Wencong Yang; Ge Zou; Shenyu Chen; Jiyan Pang; Zhigang She

doi:10.1016/j.fitote.2019.104369

Bioactive polyketides from the mangrove endophytic fungi Phoma sp. SYSU-SK-7

Fitoterapia. 2019 Nov:139:104369. doi: 10.1016/j.fitote.2019.104369. Epub 2019 Oct 15.

Authors

Yan Chen¹, Wencong Yang², Ge Zou², Shenyu Chen², Jiyan Pang², Zhigang She³

Affiliations

¹ School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China; School of Marin Sciences, Sun Yat-sen University, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China.
² School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China.
³ School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China; School of Marin Sciences, Sun Yat-sen University, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. Electronic address: cesshzhg@mail.sysu.edu.cn.

PMID: 31626911
DOI: 10.1016/j.fitote.2019.104369

Abstract

Five new polyketides, colletotric B (2), 3-hydroxy-5-methoxy-2,4,6-trimethylbenzoic acid (3), colletotric C (4), chaetochromone D (6) and 8-hydroxy-pregaliellalactone B (9), together with four known analogues (1, 5 and 7-8) were isolated from the mangrove endophytic fungus Phoma sp. SYSU-SK-7. Their structures were elucidated by analysis of extensive spectroscopic data and mass spectrometric data. Compounds 1-2 showed strong antimicrobial activity against the P. aeruginosa, MRSA and C. albicans with the MIC values in the range of 1.67-6.28 μg/ml. Furthermore, Compounds 1-5 also exhibited significant α-glucosidase inhibitory activity with the IC₅₀ values in the range of 36.2-90.6 μM. Compound 7 was found to inhibited radical scavenging activity against DPPH with the EC₅₀ value of 11.8 μM.

Keywords: Antimicrobial activity; DPPH scavenging activity; Phoma sp.; Polyketides; α-glucosidase inhibitory activity.

MeSH terms

Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology*
Ascomycota / chemistry*
China
Endophytes / chemistry
Free Radical Scavengers / isolation & purification
Free Radical Scavengers / pharmacology*
Glycoside Hydrolase Inhibitors / isolation & purification
Glycoside Hydrolase Inhibitors / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Polyketides / isolation & purification
Polyketides / pharmacology*
Rhizophoraceae / microbiology*

Substances

Anti-Infective Agents
Free Radical Scavengers
Glycoside Hydrolase Inhibitors
Polyketides