SnapShot: S-Phase Entry and Exit

Andrew Burgess; Jenny Vuong; Kamila A Marzec; Ulrik Nicolai de Lichtenberg; Seán I O'Donoghue; Lars Juhl Jensen

doi:10.1016/j.cell.2019.09.031

SnapShot: S-Phase Entry and Exit

Cell. 2019 Oct 17;179(3):802-802.e1. doi: 10.1016/j.cell.2019.09.031.

Authors

Andrew Burgess¹, Jenny Vuong², Kamila A Marzec¹, Ulrik Nicolai de Lichtenberg³, Seán I O'Donoghue², Lars Juhl Jensen⁴

Affiliations

¹ ANZAC Research Institute, University of Sydney, Sydney NSW 2139, Australia.
² Garvan Institute of Medical Research, Sydney NSW 2010, Australia; Data61, CSIRO, Sydney NSW 2015, Australia.
³ Novo Nordisk Foundation, Tuborg Havnevej 19, Hellerup 2900, Denmark.
⁴ NNF Center for Protein Research, University of Copenhagen, 2200 Copenhagen N., Denmark.

PMID: 31626778
DOI: 10.1016/j.cell.2019.09.031

Abstract

S-phase entry and exit are regulated by hundreds of protein complexes that assemble "just in time," orchestrated by a multitude of distinct events. To help understand their interplay, we have created a tailored visualization based on the Minardo layout, highlighting over 80 essential events. This complements our earlier visualization of M-phase, and both can be displayed together, giving a comprehensive overview of the events regulating the cell division cycle. To view this SnapShot, open or download the PDF.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Cycle / genetics*
Cell Division / genetics
Cyclin B / genetics
Cyclin D / genetics
Cyclin-Dependent Kinases / genetics
G2 Phase / genetics
Humans
Mitosis / genetics*
Multiprotein Complexes / genetics*
Phosphorylation / genetics
Proteasome Endopeptidase Complex / genetics
S Phase / genetics*

Substances

Cyclin B
Cyclin D
Multiprotein Complexes
Cyclin-Dependent Kinases
Proteasome Endopeptidase Complex