Three new triterpenoids, 2α, 3α, 20β, 23-tetrahydroxyurs-13 (18)-en-28-oic-acid (1) (Figure 1), 2β, 3α, 20β, 23-tetrahydroxyurs-13(18)-en-28-oic-acid (2), and 2α, 3α-dihydroxyurs-12(13), 18(19)-dien-28-oic-acid (3) were isolated from the roots of R. cymosa. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and IR spectroscopic analyses data. All the isolates were evaluated for their α-glucosidase inhibitory and anti-inflammatory activities in vitro. The results showed that compound 2 displayed moderate anti-inflammatory activity with IC50 value of 9.4 μM.
Keywords: R. cymosa; anti-inflammatory; triterpenes.