Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia

J Perinatol. 2020 Feb;40(2):263-268. doi: 10.1038/s41372-019-0523-6. Epub 2019 Oct 17.

Abstract

Objective: The objective of this study was to use current national data to evaluate the characteristics and survival trends of preterm infants born with CDH from 2004 to 2014.

Study design: Data was queried from the National Inpatient Sample (NIS) and KID database from 2004 to 2014. Infants were included if diagnosed with CDH by ICD-9 coding and gestational age <37 weeks. Descriptive statistics, chi-square, and trend analysis were completed.

Results: We identified 2356 infants born prematurely with CDH. The overall survival rate was 49%. The survival range is 21.2-62.3% for gestational age <26 weeks to 35-36 weeks, respectively. Total mortality was 1183; of them, 1052 (89%) were not repaired and 363 (30.7%) did not receive mechanical ventilation. Surgical repair occurred in 55.1% of infants.

Conclusions: Preterm infants have lower survival compared with term infants. Survival rates decrease with lower gestational age and have improved over time.

MeSH terms

  • Age Factors
  • Databases, Factual
  • Extracorporeal Membrane Oxygenation
  • Female
  • Gestational Age
  • Hernias, Diaphragmatic, Congenital / mortality*
  • Hernias, Diaphragmatic, Congenital / surgery
  • Hernias, Diaphragmatic, Congenital / therapy
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / mortality*
  • Infant, Premature, Diseases / surgery
  • Infant, Premature, Diseases / therapy
  • Length of Stay
  • Male
  • Respiration, Artificial
  • Survival Rate
  • United States / epidemiology