MicroRNA delivery through nanoparticles

Sharon Wei Ling Lee; Camilla Paoletti; Marco Campisi; Tatsuya Osaki; Giulia Adriani; Roger D Kamm; Clara Mattu; Valeria Chiono

doi:10.1016/j.jconrel.2019.10.007

MicroRNA delivery through nanoparticles

J Control Release. 2019 Nov 10:313:80-95. doi: 10.1016/j.jconrel.2019.10.007. Epub 2019 Oct 14.

Authors

Sharon Wei Ling Lee¹, Camilla Paoletti², Marco Campisi², Tatsuya Osaki³, Giulia Adriani⁴, Roger D Kamm⁵, Clara Mattu⁶, Valeria Chiono²

Affiliations

¹ Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy; Singapore-MIT Alliance for Research & Technology (SMART), BioSystems and Micromechanics (BioSyM), Singapore, Singapore(3); Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore(3); Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research, Singapore, Singapore(3).
² Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.
³ Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, Room NE47-321, Cambridge, MA, 02139, USA; Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan(3).
⁴ Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research, Singapore, Singapore(3); Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore.
⁵ Singapore-MIT Alliance for Research & Technology (SMART), BioSystems and Micromechanics (BioSyM), Singapore, Singapore(3); Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, Room NE47-321, Cambridge, MA, 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 500 Technology Square, Room NE47-321, Cambridge, MA, 02139, USA.
⁶ Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy. Electronic address: Clara.mattu@polito.it.

Abstract

MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.

Keywords: Biomaterials; MicroRNA delivery and release; Nanoparticles; Personalized medicine; Physicochemical characterization.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials / chemistry*
Delayed-Action Preparations / chemistry*
Humans
Lipids / chemistry
Metal Nanoparticles / chemistry
MicroRNAs / chemistry*
Molecular Targeted Therapy
Nanocapsules / chemistry*
Neoplasms / genetics
Neoplasms / therapy
Neurodegenerative Diseases / genetics
Neurodegenerative Diseases / therapy
Polymers / chemistry
Precision Medicine
Regeneration / genetics
Silicon Dioxide / chemistry
Transfection

Substances

Biocompatible Materials
Delayed-Action Preparations
Lipids
MicroRNAs
Nanocapsules
Polymers
Silicon Dioxide

Grants and funding

U01 CA214381/CA/NCI NIH HHS/United States