Objective: To evaluate the antibacterial activity of Aspirin, Mefenamic acid and Acetaminophen against Pseudomonas aeruginosa and Staphylococcus epidermidis biofilms.
Methods: The study was conducted AKU Karachi in collaboration with DIHE Karachi from March 2018 to December 2018.Quantitative spectrophotometric method was used to study the reduction and removal of the Pseudomonas aeruginosa and Staphylococcus epidermidis formed biofilms. Statistical tests were performed using Graph Pad Prism software. .
Results: Acetaminophen showed maximum biofilm reduction activity against the biofilms formed by Pseudomonas aeruginosa, and Staphylococcus epidermidis. Mefanamic acid showed maximum biofilm removal potential against Pseudomonas aeruginosa, while Aspirin and Mefanamic acid were equally effective in removing biofilms formed by Staphylococcus epidermidis as well.
Conclusions: There is a continuous need to look for non-antibiotic agents for their potential antimicrobial and antibiofilm potential.
Keywords: Antibiofilm activity, Aspirin, Mefenamic acid, Acetaminophen, P. aeruginosa, S. epidermidis biofilms. (JPMA 69: 1493; 2019).doi:10.5455/JPMA.295488.