Natural Hydrogels Applied in Photodynamic Therapy

Zhipan Feng; Shiying Lin; Andrew McDonagh; Chen Yu

doi:10.2174/0929867326666191016112828

Natural Hydrogels Applied in Photodynamic Therapy

Curr Med Chem. 2020;27(16):2681-2703. doi: 10.2174/0929867326666191016112828.

Authors

Zhipan Feng¹, Shiying Lin¹, Andrew McDonagh², Chen Yu¹

Affiliations

¹ School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
² University of Technology Sydney, Sydney NSW 2007, Australia.

PMID: 31622196
DOI: 10.2174/0929867326666191016112828

Abstract

Natural hydrogels are three-dimensional (3D) water-retaining materials with a skeleton consisting of natural polymers, their derivatives or mixtures. Natural hydrogels can provide sustained or controlled drug release and possess some unique properties of natural polymers, such as biodegradability, biocompatibility and some additional functions, such as CD44 targeting of hyaluronic acid. Natural hydrogels can be used with photosensitizers (PSs) in photodynamic therapy (PDT) to increase the range of applications. In the current review, the pertinent design variables are discussed along with a description of the categories of natural hydrogels available for PDT.

Keywords: PDT; Photodynamic therapy; ROS; hydrogel; natural polymer; reactive oxygen species..

MeSH terms

Drug Liberation
Hyaluronic Acid
Hydrogels
Photochemotherapy*
Photosensitizing Agents

Substances

Hydrogels
Photosensitizing Agents
Hyaluronic Acid