Hepatitis E seroprevalence and associated risk factors in Croatian liver transplant recipients

Rev Soc Bras Med Trop. 2019 Oct 10:52:e20190302. doi: 10.1590/0037-8682-0302-2019. eCollection 2019.

Abstract

Introduction: Solid-organ transplant recipients are at risk of hepatitis E virus (HEV) infection. We analyzed the seroprevalence/risk factors of HEV in Croatian liver transplant recipients.

Methods: Two hundred forty-two serum samples were tested for HEV immunoglobuline IgG/IgM and HEV RNA. Sociodemographic data and risk factors were collected using a questionnaire.

Results: HEV IgG seroprevalence rate was 24.4%. Positive/equivocal HEV IgM were found in two patients. HEV RNA was not detected. Logistic regression showed that older age, female gender, rural area/farm, water well, and septic tank were associated with HEV seropositivity.

Conclusions: This study revealed a high exposure rate to HEV in Croatian liver recipients.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Croatia / epidemiology
  • Cross-Sectional Studies
  • Female
  • Hepatitis Antibodies / blood
  • Hepatitis E / epidemiology*
  • Hepatitis E / immunology
  • Hepatitis E virus / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • RNA, Viral / blood
  • Risk Factors
  • Seroepidemiologic Studies
  • Socioeconomic Factors

Substances

  • Hepatitis Antibodies
  • Immunoglobulin G
  • Immunoglobulin M
  • RNA, Viral