Evaluating access to oral anti-diabetic medicines: A cross-sectional survey of prices, availability and affordability in Shaanxi Province, Western China

PLoS One. 2019 Oct 16;14(10):e0223769. doi: 10.1371/journal.pone.0223769. eCollection 2019.

Abstract

Objectives: To assess the availability and affordability of oral anti-diabetic medicines in Shaanxi Province, Western China.

Methods: In 2015, the prices and availability of 8 anti-diabetic medicines covering 31 different dosage forms and strengths were collected in six cities of Shaanxi Province. A total of 72 public hospitals and 72 private pharmacies were sampled, using a modified methodology developed by the World Health Organization (WHO) and Health Action International (HAI). Medicine prices were compared with international reference prices to obtain a median price ratio. For urban residents, affordability was assessed as the lowest-paid unskilled government workers to purchase cost of standard treatment in days' wages; for rural residents, days' net income was used.

Results: The mean availabilities of originator brands (OBs) and generics were 34.3% and 28.7% in public hospitals, and 44.1% and 64.4% in the private pharmacies. OBs and the lowest priced generics (LPGs) were procured at 12.38 and 4.52 times the international reference price in public hospitals, and 10.26 and 2.81 times the international reference prices in private pharmacies. Treatments with OBs were unaffordable even for urban residents. The affordability of the LPGs was good, except for acarbose, repaglinide and pioglitazone.

Conclusions: Most anti-diabetic medicines cannot met the WHO's availability target (80% availability) in Shaanxi Province. The high prices of OBs had severely influenced the affordability of medicines, especially for the rural residents. Effective policies should be initiated to ensure the Chinese people a better access to more affordable anti-diabetic medicines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • China
  • Costs and Cost Analysis
  • Cross-Sectional Studies
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / economics
  • Drugs, Essential / administration & dosage
  • Drugs, Essential / economics
  • Drugs, Essential / supply & distribution
  • Drugs, Generic / administration & dosage
  • Drugs, Generic / economics
  • Drugs, Generic / supply & distribution
  • Health Policy
  • Health Services Accessibility / economics*
  • Health Services Accessibility / statistics & numerical data
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Hypoglycemic Agents / economics
  • Hypoglycemic Agents / supply & distribution*
  • Policy Making
  • Prescription Drugs / administration & dosage
  • Prescription Drugs / economics
  • Prescription Drugs / supply & distribution
  • Socioeconomic Factors
  • Surveys and Questionnaires

Substances

  • Drugs, Essential
  • Drugs, Generic
  • Hypoglycemic Agents
  • Prescription Drugs

Grants and funding

This work was supported by National Natural Science Foundation of China (http://www.nsfc.gov.cn/) under award number 71503197 [PI CJ Yang] and number 71473192 [PI Y Fang] and“the Fundamental Research Funds for the Central Universities” (http://www.xjtu.edu.cn) without award number [PI CJ Yang].The funders had no role in study design, data collection and analysis, decisionto publish, or preparation of the manuscript.