New Diagnosis of Acquired Immunodeficiency Syndrome in a Patient With Crohn's Disease

Maya Aharoni Golan; Roni Weisshof; Yunwei Wang; David T Rubin

doi:10.14309/crj.0000000000000056

New Diagnosis of Acquired Immunodeficiency Syndrome in a Patient With Crohn's Disease

ACG Case Rep J. 2019 Apr 8;6(4):e00056. doi: 10.14309/crj.0000000000000056. eCollection 2019 Apr.

Authors

Maya Aharoni Golan¹, Roni Weisshof¹, Yunwei Wang¹, David T Rubin¹

Affiliation

¹ Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL.

Abstract

There are limited data on the natural history of Crohn's disease (CD) in the presence of human immunodeficiency virus infection and the safety of available treatments. We report a patient with CD who presented with pneumocystis pneumonia secondary to newly diagnosed acquired immunodeficiency syndrome. One month before his admission, his gastrointestinal symptoms were well controlled without treatment but gradually reappeared after antiretroviral therapy was initiated. Clinical remission was achieved with vedolizumab treatment. We review the management challenges of CD in a patient with human immunodeficiency virus and describe the unique mechanism of anti-α4β7 integrin therapy in this setting.