Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Ming-Xin Cao; Ya-Ling Tang; Wei-Long Zhang; Ya-Jie Tang; Xin-Hua Liang

doi:10.3389/fonc.2019.00916

Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Front Oncol. 2019 Sep 20:9:916. doi: 10.3389/fonc.2019.00916. eCollection 2019.

Authors

Ming-Xin Cao¹, Ya-Ling Tang², Wei-Long Zhang², Ya-Jie Tang^{3

4}, Xin-Hua Liang¹

Affiliations

¹ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
² State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
³ State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
⁴ Hubei Key Laboratory of Industrial Microbiology, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan, China.

Abstract

Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationship with pathological conditions such as lymphatic developmental diseases, inflammation, and cancer. This review summarizes the molecular mechanisms of lymphangiogenesis in lymphatic development, inflammation and cancer metastasis, and discusses ncRNAs' regulatory effects on them. Therapeutic targets with regard to lymphangiogenesis are also discussed.

Keywords: cancer metastasis; inflammation; lymphangiogenesis; lymphatic development; non-coding RNA (ncRNA).

Publication types

Review