Clinical characteristics of testicular seminoma in individuals in West China: a 10-year follow-up study

Zeyu Chen; Shi Qiu; Dehong Cao; Jianbing Guo; Bo Chen; Yin Huang; Li Lai; Yige Bao; Qiang Dong; Liangren Liu; Qiang Wei

doi:10.2147/CMAR.S215537

Clinical characteristics of testicular seminoma in individuals in West China: a 10-year follow-up study

Cancer Manag Res. 2019 Aug 14:11:7639-7645. doi: 10.2147/CMAR.S215537. eCollection 2019.

Authors

Zeyu Chen^#^{1

2}, Shi Qiu^#^{1

3}, Dehong Cao^#¹, Jianbing Guo^{1

2}, Bo Chen^{1

2}, Yin Huang^{1

2}, Li Lai¹, Yige Bao¹, Qiang Dong¹, Liangren Liu¹, Qiang Wei¹

Affiliations

¹ Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
² West China School of Medicine, Sichuan University, Chengdu, People's Republic of China.
³ Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

^# Contributed equally.

Abstract

Objective: To assess the clinical characteristics of testicular seminoma (TS).

Patients and methods: A testicular cancer (TC) survey was conducted by the Department of Urology, West China Hospital, between 2008 and 2018. Tumors were classified according to the NCCN criteria such as age, tumor size, tumor marker levels, histopathology, clinical stage, initial treatment, follow-up, and clinical outcomes, were obtained from the database of our center.

Results: Among 155 registered cases of TC with seminomatous element, 127 cases of pure TS were analyzed. All 127 patients with a median age of 37 years were pathologically diagnosed with orchiectomy specimens. Orchiectomy, chemotherapy, and radiotherapy were the main treatments for these patients. Patients with clinical stages I, II, and III testicular cancer of accounted for 81.1% (n=103), 15.7% (n=20), and 3.2% (n=4) of all patients, respectively. After a median follow-up time of 50 months, five patients presented with relapse during follow-up, and one among them died. Of the patients with stage I TS (T1N0M0S0 CS IA), three patients who only underwent orchiectomy relapsed. Among patients with stage II TS (T1N1M0S1 CS IIA), one patient relapsed after orchiectomy, post-surgery chemotherapy and radiotherapy. In four patients with stage III disease (T2N1M1aS1 CS IIIA), one relapsed after orchiectomy and chemotherapy, and died shortly after salvage chemotherapy and radiotherapy due to recurrence. The median overall survival time was 50 months. In all patients, the 2-year overall survival and progression-free survival probabilitis were 98.6% and 98.8%, respectively.

Conclusion: The present study shows that patients with TS have good prognosis even at an advanced stage. Surveillance after orchiectomy was important for patients with CSI seminoma, and we recommend cisplatin-based chemotherapy as salvage therapy for patients with CSI seminoma. In addition, patients with a maximal tumor diameter >4 cm should undergo post-surgery chemotherapy.

Keywords: orchiectomy; post-orchiectomy therapy; testicular cancer; testicular seminoma.